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Recurrent HSR in the centromeric region of chromosome 8 in breast cancer
M Gerbault-Seureau1, P Vielh, B Dutrillaux
1UA 620 CNRS, Institut Curie, Paris.
Annales De Genetique
|January 1, 1987
Abstract:
In a sample of 44 human breast cancers, the presence of HSRs was detected in 15 cases (36%). The occurrence of HSRs seems correlated poorly with tumor progression, but the number of HSRs per cell certainly does. Chromosome 8 was the most frequently involved, and the HSRs were always located near its centromere, suggesting that an amplification of gene(s) located in this region has occurred. Among these, LHRH is a candidate, but further studies are needed to confirm or reject this hypothesis.