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Published on: February 14, 2021
Understanding associations between rumination and inflammation: A scoping review
Yvette Z Szabo1, Christina M Burns2, Crystal Lantrip3
1Department of Veterans Affairs, VISN 17 Center of Excellence for Research on Returning War Veterans, 4800 Memorial Drive (151C), Waco, TX, 76711, United States; Department of Health, Human Performance and Recreation, Baylor University, 97313 One Bear Place, Waco, TX, 76798, United States.
Focused attention on negative events (rumination) may increase inflammation, impacting long-term health. Experimental studies show a clearer link between rumination and inflammation markers.
Area of Science:
- Psychology
- Physiology
- Health Sciences
Background:
- Rumination, or dwelling on negative thoughts, is increasingly linked to adverse health outcomes.
- Inflammation is a key biological process implicated in numerous chronic diseases.
Purpose of the Study:
- To conduct a scoping review of quantitative human studies examining the association between rumination and inflammation.
- To synthesize current evidence on the physiological consequences of rumination.
Main Methods:
- Systematic search and review of quantitative studies on rumination and inflammation.
- Inclusion of 13 studies with 1,102 participants, analyzing 8 inflammation biomarkers (e.g., C-reactive protein, IL-6).
Main Results:
- A consistent association between higher rumination and increased inflammation was observed, particularly in experimental studies manipulating rumination.
- Emerging evidence suggests potential interactions between rumination, socioeconomic status, and anxiety in predicting inflammation levels.
Conclusions:
- The relationship between rumination and inflammation is complex and may depend on how rumination is defined and measured.
- Further research is needed to understand the nuances of this association, including its modulation by other factors and measurement contexts (rest vs. stress).
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