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Related Experiment Videos

Pharmacological interventions for motion sickness: cardiovascular effects.

F A Sunahara1, J Farewell, L Mintz

  • 1Department of Pharmacology, University of Toronto, Ontario, Canada.

Aviation, Space, and Environmental Medicine
|September 1, 1987
PubMed
Summary

Forearm blood flow increases during motion sickness (MS). This blood flow change may serve as an objective measure for susceptibility to motion sickness, aiding in future research.

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Area of Science:

  • Neuroscience
  • Human Physiology
  • Aerospace Medicine

Background:

  • Motion sickness (MS) is a common sensory disorder.
  • Current methods for assessing MS susceptibility lack objectivity.
  • Understanding physiological correlates of MS is crucial for developing countermeasures.

Purpose of the Study:

  • To investigate physiological changes during motion sickness.
  • To determine if forearm blood flow (BF) can serve as an objective index for MS susceptibility.
  • To evaluate the efficacy of certain anti-motion sickness medications.

Main Methods:

  • Healthy volunteers were subjected to rotational stimuli with head movements (HM) to induce MS.
  • Arterial blood pressure (BP), heart rate (HR), and forearm blood flow (BF) were monitored.

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  • Venous occluding plethysmography was used to measure forearm BF.
  • Medications including scopolamine:d-amphetamine, promethazine:ephedrine, and naproxen were administered.

    • Main Results:

    • No consistent changes in BP or HR were observed.
    • Marked increases in forearm BF were associated with MS.
    • An inverse correlation existed between HM tolerance duration and BF increments.
    • Promethazine:ephedrine reduced HM-induced hyperemic responses but did not increase HM duration.
    • Naproxen did not significantly alter HM duration or BF responses.

    Conclusions:

    • Forearm blood flow changes represent a potential objective biomarker for motion sickness susceptibility.
    • Pharmacological interventions show varied effects on MS symptoms and physiological responses.
    • Further research is warranted to validate BF as a reliable index for MS.