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Dendrimer nanoplatforms for veterinary medicine applications: A concise overview
Serge Mignani1, Xiangyang Shi2, João Rodrigues3
1Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, Rue des Saints Peres, 75006 Paris, France; CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.
Dendrimers, a type of nanoparticle, show promise in veterinary nanomedicine for treating viral diseases like foot-and-mouth disease and swine fever in animals. Various administration routes ensure successful application in diverse animal species.
Area of Science:
- Nanomedicine
- Veterinary Therapeutics
- Nanoparticle Applications
Background:
- Dendrimers are advanced nanoparticles gaining traction in nanomedicine.
- Their application is expanding beyond human to veterinary medicine.
- This represents a novel therapeutic avenue for animal health.
Purpose of the Study:
- To review the current and potential applications of dendrimers in veterinary medicine.
- To highlight dendrimers' role in combating significant animal viral diseases.
- To discuss the efficacy of different administration routes for dendrimers in animals.
Main Methods:
- Literature review of dendrimer applications in veterinary medicine.
- Identification of key animal diseases targeted by dendrimer therapies.
- Analysis of administration routes (intramuscular, subcutaneous, intravenous, intraperitoneal) for dendrimer efficacy.
Main Results:
- Dendrimers are effective against foot-and-mouth disease virus (FMDV) and swine fever virus (SFV) in pigs.
- Applications include FMDV in cattle, hypothermic circulatory arrest (HCA) in dogs, rabies, and H9N2 avian influenza in chickens.
- Successful dendrimer delivery demonstrated via intramuscular, subcutaneous, intravenous, and intraperitoneal routes.
Conclusions:
- Dendrimers offer a versatile nanomedicine platform for veterinary applications.
- They present a promising strategy for managing and treating infectious viral diseases in livestock and companion animals.
- Effective administration routes support the broad applicability of dendrimers in animal health.
