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Updated: Oct 7, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Alterins, a new family of marine antibacterial cyclolipopeptides
Clément Offret1, Héléna Cuny1, Pierre-Edouard Bodet2
1Univ Brest, Univ. Bretagne Sud, Laboratoire de Biotechnologie et Chimie Marine, EA3884, F-29334 Quimper, France.
Abstract:
Five strains of Pseudoalteromonas, isolated from oyster haemolymph, have exhibited antibacterial activity against several Gram-negative bacteria. Bioactive compounds have been identified in their cell-free supernatant and characterised as alterins, which are cyclolipopeptides comprising a heptapeptidic ring connected to a fatty acid chain. Using ultra-performance liquid chromatography-high-resolution mass spectrometry, this paper describes 37 structural analogues differing from each other by one or more amino acid residue, the length of the fatty acid chain, its hydroxylation and the presence of unsaturation.
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