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The therapeutic effects of basic fibroblast growth factor in nasal vestibulitis
Hong Liu1, Hua Yang1, Jing-Jing Zhao1
1Department of Otolaryngology, the Fifth People's Hospital of Ningxia Autonomous Region, 753000, Ningxia Autonomous Region, China.
Objective:
To observe the effect of topical application of recombinant human basic fibroblast growth factor (bFGF) in patients with nasal vestibulitis.
Methods:
One hundred patients with nasal vestibulitis were randomly divided into two groups. Local application of bFGF + conventional medication was administered in the treatment group, while conventional medication was conducted in the control group. The healing of the nasal vestibular mucosa was observed.
Results:
The mucosal healing time was 18.3 ± 4.8 days in the treatment group and 36.2 ± 6.2 days in the control group. The data comparison revealed that the difference between groups was statistically significant (P < 0.01). The total effective rate was 98.0% in the treatment group and 90.0% in the control group, and the difference was not statistically significant between the two groups (P > 0.05).
Conclusion:
Topical application of bFGF in patients with nasal vestibulitis could promote the growth of nasal mucosa, shorten the healing time of mucosal erosion, enhance the clinical treatment effect, and save a lot of treatment time for patients.
