Hacking macrophages to combat cancer and inflammatory diseases - Current advances and challenges

Recently, immunotherapy has been served as the treatment of choice for various human pathophysiologies, including inflammatory diseases and cancer. Though most of the current approaches target the lymphoid compartment, macrophages intimately implicated in the induction or resolution of inflammation have rationally gained their place into the therapeutics arena. In this review, I discuss the past and novel ground-breaking strategies focusing on macrophages in different human diseases and highlight the current challenges and considerations underlying their translational potentials.