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Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents
D Sauvaire1, A Michel, J J Serrano
1Laboratoires Richard-Sauzet, Montelimar, France.
Drugs Under Experimental and Clinical Research
|January 1, 1987
Abstract:
An experimental and comparative study was conducted on 1-(p-chlorobenzoyl)-2-methyl-5-methoxyindole-3-p-acetamidophenol acetate (Apyramide) and known anti-inflammatory agents. Apyramide was far less toxic than indomethacin in rats and mice by the oral or the i.p. route. It exhibited anti-inflammatory activity on carrageenin-induced paw oedema, cotton pellet granuloma and adjuvant arthritis, as well as analgesic and antipyretic activities. The acute ulcerogenic effect of Apyramide was lower than that of indomethacin.