Microemulsion-Confined Assembly of Magnetic Nanoclusters for pH/H₂O₂ Dual-Responsive T₂-T₁ Switchable MRI

In this work, a T₂-T₁ switchable superparamagnetic iron oxide nanoprobe with a pH/H₂O₂ dual response was obtained using a microemulsion method. This novel method for the controllable assembly of small iron clusters followed by their independent modification was reported, which could not be prepared by common synthetic methods. The size of the assembled nanoprobe was uniform and controllable, with a stable T₂ magnetic resonance imaging (MRI) signal under a single condition. When the nanoprobe was exposed to the tumor environment, the higher H⁺ and H₂O₂ concentrations at the tumor site could dissociate the nanoprobe and redisperse into small iron clusters. When this occurred, the T₂ MRI signal was converted into a T₁ MRI signal, achieving specific detection of tumors by a pH/H₂O₂ dual-response T₂-T₁ MRI.