Related Experiment Video

Updated: Oct 7, 2025

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
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Published on: December 6, 2016

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Imaging Markers of Vascular Brain Health: Quantification, Clinical Implications, and Future Directions

Prashanthi Vemuri1, Charles Decarli2, Marco Duering3,4

  • 1Department of Radiology, Mayo Clinic, Rochester, MN (P.V.).

Stroke
|January 10, 2022
PubMed

Insights

Cerebrovascular disease (CVD) impacts brain health, but is often overlooked in dementia research. New magnetic resonance imaging methods offer promising biomarkers for aging and cognitive decline.

Area of Science:

  • Neurology
  • Radiology
  • Gerontology

Background:

  • Cerebrovascular disease (CVD) significantly affects brain and cognitive health.
  • CVD's impact is often underestimated in aging and dementia research, leading to incomplete understanding of cognitive impairment causes.

Purpose of the Study:

  • To review current magnetic resonance imaging (MRI) methods for measuring CVD lesions and small vessel disease.
  • To discuss the clinical relevance of CVD imaging markers for cognitive decline, dementia, and Alzheimer's disease progression.
  • To provide an outlook on future challenges and opportunities in CVD imaging biomarker research.

Main Methods:

  • Review of current magnetic resonance imaging (MRI) techniques.
  • Analysis of clinical implications of CVD imaging markers.
  • Discussion of research trends and future perspectives.

Main Results:

  • MRI methods are advancing for detecting CVD lesions and early small vessel disease.
  • CVD imaging markers show relevance for cognitive decline and dementia progression.
  • Reliable CVD imaging biomarkers for aging and dementia studies are anticipated.

Conclusions:

  • CVD is a critical factor in cognitive impairment and dementia.
  • Advanced MRI techniques are crucial for identifying CVD-related brain injury.
  • Further research into CVD imaging biomarkers will enhance understanding of aging and dementia.

Keywords:
Alzheimer diseasebiomarkersbraincerebrovascular diseasecognitiondementia

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