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Modified-Release Drug Delivery Systems: Bioavailability

Modified-Release Drug Delivery Systems: Bioavailability

Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Updated: Jul 19, 2026

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Curcumin delivery by modified biosourced carbon-based nanoparticles.

Hossein Danafar¹, Marziyeh Salehiabar¹, Murat Barsbay²

¹Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.

Nanomedicine (London, England)

|January 10, 2022

Summary

A novel hybrid nanoparticle system (CBNPs@BSA-CUR) was developed for controlled curcumin delivery. This non-toxic system shows promise for cancer therapy, demonstrating good biocompatibility and antiproliferative effects.

Keywords:

BSA bioinspired nanoparticles biosourced carbon nanoparticles curcumin ultrasound-assisted treatment

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Last Updated: Jul 19, 2026

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Area of Science:

Nanotechnology
Materials Science
Biomedical Engineering

Background:

Curcumin (CUR) has therapeutic potential but suffers from poor bioavailability.
Developing effective drug delivery systems is crucial for enhancing CUR's efficacy.
Nanocarriers offer a promising approach for targeted and controlled drug release.

Purpose of the Study:

To develop a novel hybrid system for controlled curcumin delivery.
To synthesize and characterize protein-modified carbon-based nanoparticles loaded with curcumin.
To evaluate the drug release behavior, biocompatibility, and anticancer activity of the developed system.

Main Methods:

Ultrasound-assisted fabrication of protein-modified nanosized graphene oxide-like carbon-based nanoparticles (CBNPs).
Loading of curcumin (CUR) onto bovine serum albumin (BSA)-modified CBNPs (CBNPs@BSA-CUR).
Characterization using TEM, AFM, UV-Vis, FTIR, and XPS; evaluation of pH-sensitive release, biocompatibility, and antiproliferative activity against MCF-7 cells.

Main Results:

Successfully synthesized and characterized CBNPs@BSA-CUR nanoparticles.
Demonstrated pH-sensitive and controlled release of curcumin.
The drug-free system showed good biocompatibility and was non-toxic.
CBNPs@BSA-CUR exhibited acceptable antiproliferative activity against MCF-7 breast cancer cells.

Conclusions:

CBNPs@BSA-CUR represents a promising nanocarrier for curcumin delivery.
The system exhibits controlled release, good biocompatibility, and potential for cancer therapy.
Further research into this non-toxic nanocarrier could advance curcumin-based treatments.