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Hormone replacement therapy - Current recommendations.

Kugajeevan Vigneswaran1, Haitham Hamoda1

  • 1King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.

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|January 10, 2022
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Summary
This summary is machine-generated.

Hormone replacement therapy (HRT) is used by about a million UK women for menopausal symptom control. This review examines current HRT recommendations, covering benefits, risks, and long-term health impacts.

Keywords:
EstrogensHormone replacement therapyMenopauseProgestogens

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Area of Science:

  • Reproductive Endocrinology
  • Women's Health

Background:

  • Menopause, averaging age 51 in the UK, signifies the end of reproductive life.
  • It results from oocyte exhaustion, leading to a hypo-estrogenic state with short-term symptoms and long-term effects on bone and cardiovascular health.
  • Hormone replacement therapy (HRT) prescription rates declined after major studies but remains a key treatment for approximately one million UK women.

Purpose of the Study:

  • To summarize current recommendations for HRT use in menopausal women.
  • To discuss the benefits of HRT for menopausal symptom management.
  • To review the evidence on HRT's role in managing long-term health consequences and associated risks.

Main Methods:

  • Literature review of current recommendations and evidence.
  • Analysis of benefits and risks of HRT.
  • Examination of HRT's impact on menopausal symptoms and long-term health.

Main Results:

  • HRT effectively improves menopausal symptoms.
  • HRT has a role in managing long-term sequelae of menopause.
  • Evidence regarding the risks associated with HRT is also reviewed.

Conclusions:

  • Current recommendations guide HRT use for menopausal symptom management.
  • HRT offers benefits for symptom relief and potentially long-term health.
  • A balanced review of HRT's benefits and risks is essential for clinical decision-making.