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Updated: Oct 7, 2025
Generating and Imaging Mouse and Human Epithelial Organoids from Normal and Tumor Mammary Tissue Without Passaging
Published on: November 11, 2022
Modeling tumor plasticity in organoid models of human cancer
John R Christin1, Michael M Shen1
1Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Urology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Abstract:
Due to its inherent plasticity and heterogeneity, cancer is a difficult disease to model both in vitro and in vivo. However, recent advances in organoid technology hold great promise for future research into the mechanisms underlying tumor plasticity in human cancers.
