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Updated: Oct 7, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

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When breaks get hot: inflammatory signaling in BRCA1/2-mutant cancers

Marcel A T M van Vugt1, Eileen E Parkes2

  • 1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands.

Trends in Cancer
|January 10, 2022
PubMed
Abstract

Keywords:
BRCA1BRCA2STINGcGASgenomic instabilityimmune checkpointsinflammationmitosis

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