[THE LEVEL OF S100Β IN BLOOD SERUM AS A PROGNOSTIC FACTOR OF OUTCOME IN SECONDARY BRAIN LESIONS]

Area of Science:

• Neuroscience
• Biomarkers
• Clinical Medicine

Background:

• Brain injuries, including vascular and traumatic types, pose significant mortality risks.
• Accurate prognostic markers are crucial for managing patients with acute cerebral pathology.
• Neuron-specific markers show potential in predicting outcomes of brain damage.

Purpose of the Study:

• To investigate the prognostic value of serum S100 as a predictor of mortality in vascular and traumatic brain injuries.
• To assess the role of neuron-specific markers and other physiological indicators in determining brain damage outcomes.

Main Methods:

• A prospective cohort study of 219 patients.
• Serum neuron-specific markers (S100, NSE), glucose, and arterial blood gas composition were measured at multiple time points.
• Statistical analysis included logistic regression to determine risk factors and develop a prognostic model.

Main Results:

• Serum S100 > 0.2 mcg/l was identified as the most significant risk factor for unfavorable outcomes.
• Elevated S100 and NSE levels showed a strong association with mortality (OR=11.9).
• A prognostic model incorporating S100, NSE, pCO2, GCS, and Hb demonstrated high predictive accuracy (AUC=0.88, sensitivity=91.89%, specificity=64.14%).

Conclusions:

• Serum S100 is a valuable prognostic marker for mortality in patients with acute brain injuries.
• The developed prognostic model offers excellent predictive ability for patient outcomes.
• This model can aid in clinical decision-making for patients with acute cerebral pathology.