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Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
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Case Series: Tattoo-associated Uveitis.

Aaron S Peterson, Anthony W Patterson

    Optometry and Vision Science : Official Publication of the American Academy of Optometry
    |January 10, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Tattoo-associated uveitis links eye inflammation with skin tattoos. This case series suggests a delayed hypersensitivity reaction or localized sarcoidosis may cause this condition, resolving after tattoo removal.

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    Area of Science:

    • Ophthalmology
    • Dermatology
    • Immunology

    Background:

    • Tattoo-associated uveitis involves simultaneous inflammation of tattoos and the uvea.
    • Etiology is unclear, with systemic sarcoidosis or delayed hypersensitivity reactions previously suggested.
    • No consensus exists on the cause of tattoo-associated uveitis.

    Purpose of the Study:

    • To investigate two cases of simultaneous tattoo inflammation and bilateral anterior uveitis.
    • To explore potential etiologies, including sarcoidosis and delayed hypersensitivity reactions.
    • To evaluate treatment outcomes, including response to corticosteroids and tattoo removal.

    Main Methods:

    • Retrospective review of two African American male patients.
    • Clinical examination for uveitis and tattoo inflammation.
    • Laboratory tests and imaging to rule out systemic sarcoidosis.
    • Skin biopsies of tattoos to identify granulomas.
    • Treatment with topical/oral corticosteroids and surgical tattoo removal.

    Main Results:

    • Both patients presented with bilateral anterior uveitis and tattoo inflammation.
    • Systemic sarcoidosis was suspected but not confirmed by diagnostics.
    • Skin biopsies revealed noncaseating granulomas in tattoos.
    • Complete inflammatory resolution occurred only after tattoo removal.
    • No recurrence of inflammation was observed post-tattoo removal.

    Conclusions:

    • Tattoo-associated uveitis can manifest with noncaseating granulomas.
    • Etiology may involve a localized sarcoidosis-like reaction or a delayed hypersensitivity response to tattoo ink antigens.
    • Tattoo removal is an effective treatment for resolving inflammation and preventing recurrence.