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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Published on: May 31, 2016

Perfluoroalkyl Substances and Abdominal Aortic Calcification.

Antti Koskela¹, Alan Ducatman, John T Schousboe

¹Cancer Research and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Finland (Dr Koskela); West Virginia University School of Public Health, Morgantown, West Virginia (Dr Ducatman); Park Nicollet Osteoporosis Center and Health Partners Institute and Division of Health Policy and Management, University of Minnesota, Minneapolis, Minnesota (Dr Schousboe); Department of Population and Public Health Sciences (Dr Nahhas, Dr Khalil); Department of Psychiatry (Dr Nahhas), Boonshoft School of Medicine, Wright State University, Dayton, Ohio.

Journal of Occupational and Environmental Medicine

|January 10, 2022

Summary

Serum perfluoroalkylated substances (PFAS) were not significantly linked to abdominal aortic calcification (AAC) in adults. Further research with larger datasets is needed to explore potential gender-specific associations with PFAS exposure and cardiovascular health.

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Area of Science:

Environmental Health
Cardiovascular Disease Epidemiology
Toxicology

Background:

Perfluoroalkylated substances (PFAS) are persistent environmental contaminants with potential health implications.
Abdominal aortic calcification (AAC) is a marker of cardiovascular disease risk.
Previous research suggests potential links between environmental exposures and cardiovascular outcomes.

Purpose of the Study:

To investigate the association between serum levels of specific perfluoroalkylated substances (PFAS) and abdominal aortic calcification (AAC).
To examine potential gender-specific differences in the relationship between PFAS exposure and AAC.

Main Methods:

Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014.
Employed weighted logistic regression analysis on participants aged 40 years and older.
Assessed AAC using dual-energy X-ray absorptiometry (DXA) scans and quantified serum PFAS levels.

Main Results:

No significant association was found between serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS), or perfluorononanoic acid (PFNA) and AAC after adjusting for confounders.
A positive, though not statistically significant, association was observed for PFOA and PFOS in women.
Adjusted odds ratios ranged from 0.80 to 1.33, with all P-values greater than 0.05.

Conclusions:

Current findings do not provide broad support for a link between general PFAS exposure and AAC.
The study highlights the need for gender-specific analyses in future research on PFAS and cardiovascular health.
Larger datasets are recommended to further explore potential sex-based differences in PFAS-associated cardiovascular risks.