Toxicokinetic of cyphenothrin in rabbits

Type II pyrethroids, including cyphenothrin, have a wider efficacy and spectrum of action because they have a killing effect rather than a knockdown effect on pests. For this reason, they are among the most widely used pyrethroid groups today. In addition, this group also has repellent activity. Thus, cyphenothrin is a commonly used pyrethroid, which poses an exposure/toxicity risk for living organisms. Toxicokinetic studies have an important place in predicting the toxicity risks of compounds and evaluating viable treatment options. In this study, the toxicokinetics of cyphenothrin were investigated in rabbits. The animal material of the study comprised 6-month-old female 14 New Zealand rabbits, each weighing 2-2.5 kg. The animals were randomly assigned to two groups, each of 7 animals. The rabbits in group 1 were administered a single dose of 2.5 mg/kg bw cyphenothrin in dimethyl sulfoxide as an intravenous bolus, while the rabbits in group 2 were administered a single dose of 2.5 mg/kg bw cyphenothrin in the same vehicle as an oral bolus. Following the administration of cyphenothrin, blood samples were taken at certain intervals from the auricular vein into heparinized tubes. Plasma cyphenothrin levels were determined by gas chromatography, using a capillary column and a micro-electron capture detector. For orally administered cyphenothrin, the plasma maximum concentration (C_max), time to reach the maximum value (t_max), half-life (t_1/2β), mean residence time (MRT), area under the curve (AUC_0→∞), and bioavailability (F) values were determined as 172.28 ± 47.30 ng/ml, 1.07 ± 0.42 h, 12.95 ± 1.11 h, 17.79 ± 1.69 h, 2220.07 ± 572.02 ng/h/ml, and 29.50%, respectively. For intravenous cyphenothrin, the t_1/2β, MRT and AUC_0→∞ values were ascertained as 7.66 ± 0.74 h, 9.28 ± 0.62 h, and 7524.31 ± 2988.44 ng/h/ml, respectively. Although the bioavailability of cyphenothrin was limited when taken orally, its half-life and mean residence time in the body were found to be long. This suggests that high doses of this pesticide may pose a poisoning risk.