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Updated: Oct 7, 2025
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Predictive and prognostic effect of ABO blood group on immune checkpoint inhibitors
Yakup Ergun1, Selin Akturk Esen2, Murat Bardakci2
1Department of Medical Oncology, Batman Training and Research Hospital, Batman, Turkey.
Background:
The relationship of the ABO blood group system with the immune response is known, but its relationship with immune checkpoint inhibitors (ICIs) has not been clearly investigated until now.
Objective:
In this study, the relationship between different blood groups and nivolumab treatment response in patients with advanced malignant melanoma was investigated.
Methods:
The data of patients who used nivolumab for advanced malignant melanoma between April 2018 and April 2021 were retrospectively reviewed.
Results:
A total of 73 patients were included in the study. In the progression-free survival (PFS) analysis according to blood groups, it was 3.9 months, 16.1 months, 20.0 months and 3.0 months for A, B, AB and O, respectively (p= 0.1). Overall survival (OS) analysis according to blood groups was 5.1 months, 25.0 months, 20.0 months and 9.3 months for A, B, AB and O, respectively (p= 0.1). The B antigen group (B or AB) had significantly longer PFS and OS than the non-B antigen group (A or O) (16.1 vs. 3.5 months for PFS, respectively, p= 0.03; 20.0 vs. 7.4 months for OS, respectively, p= 0.02).
Conclusions:
The presence of B antigen provides a significant advantage in terms of survival in patients using ICIs for advanced melanoma.
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