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Clinical Features and Outcome of Stroke with COVID-19. COVID-19 Stroke Study Group (CSSG), India

Rohit Bhatia1, M V Padma Srivastava1, P N Sylaja2

  • 1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Annals of Indian Academy of Neurology
|January 10, 2022
PubMed

Insights

COVID-19 (Coronavirus Disease 19) significantly increases stroke severity and mortality. Patients with COVID-19 associated stroke (CoVS) experienced worse outcomes and higher death rates compared to those without the virus.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Stroke occurrence has been noted in patients diagnosed with COVID-19.
  • Understanding the clinical impact of COVID-19 on stroke patients is crucial.

Purpose of the Study:

  • To compare the clinical features and outcomes of stroke patients with and without COVID-19.
  • To identify predictors of mortality in stroke patients during the pandemic.

Main Methods:

  • A multicentric study involving 18 sites across India (COVID-19 Stroke Study Group).
  • Comparison of stroke patients with (CoVS) and without (non-CoVS) COVID-19 admitted between February and July 2020.
  • Collection of demographic, clinical, treatment, and outcome data.

Main Results:

  • CoVS patients exhibited higher stroke severity and greater cerebral involvement on imaging.
  • In-hospital complications, death rates, and 3-month mortality were significantly higher in CoVS patients.
  • COVID-19 infection and baseline stroke severity independently predicted mortality.

Conclusions:

  • COVID-19 associated stroke (CoVS) is linked to increased severity, poorer outcomes, and higher mortality.
  • SARS-CoV-2 infection is an independent predictor of mortality in stroke patients.
Abstract

Keywords:
COVID-19SARS-CoV-2ischemic strokestrokethrombolysis

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