AYUSH- 64: A potential therapeutic agent in COVID-19

Area of Science:

• Ayurvedic Medicine
• Pharmacology
• Infectious Disease Management

Background:

• COVID-19 pandemic presents significant global morbidity and mortality challenges.
• Management is complex due to multifactorial pathophysiology and lack of specific treatments.
• AYUSH-64, a poly-herbal formulation, has demonstrated safety and efficacy in febrile conditions.

Purpose of the Study:

• To review the specifications, mechanism of action, and repurposing of AYUSH-64 for COVID-19.
• To highlight clinical and experimental evidence supporting AYUSH-64's use.
• To inform about AYUSH-64's inclusion in national COVID-19 management protocols.

Main Methods:

• Review of pharmacological, toxicological, and clinical studies on AYUSH-64.
• Analysis of AYUSH-64's ingredients and their activities (immunomodulatory, anti-inflammatory, etc.).
• Examination of AYUSH-64's role in the Indian national COVID-19 management protocol.

Main Results:

• AYUSH-64 possesses immunomodulatory, anti-inflammatory, antipyretic, antioxidant, and antiviral properties.
• The formulation can mitigate extreme inflammatory responses associated with COVID-19 progression.
• AYUSH-64 is incorporated into India's national protocol for mild to moderate COVID-19 cases.

Conclusions:

• AYUSH-64 is a safe and effective poly-herbal formulation for managing COVID-19.
• Its properties help reduce inflammation and disease severity.
• Nationwide distribution aims to reduce hospital burden for home-isolated patients.