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ADAMTS8 Expression is a Potential Prognostic Biomarker for Postoperative Metastasis in Lymph Node-Negative
1Breast Center, Department of Thyroid-Breast-Hernia Surgery, Department of General Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Pharmacogenomics and Personalized Medicine
|January 10, 2022
Summary
Low ADAMTS8 expression in lymph node-negative early-stage breast cancer (BC) indicates a higher risk of metastasis and shorter distant metastasis-free survival (DMFS). This suggests ADAMTS8 is a potential prognostic biomarker for BC patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Invasive breast carcinoma (BC) is common, with most early-stage, lymph node-negative (LN-) patients having good prognoses.
- However, a subset of LN- BC patients experience metastasis post-surgery, necessitating better prognostic tools.
- Identifying patients at higher risk allows for tailored, intensive therapeutic strategies.
Purpose of the Study:
- To identify a reliable prognostic biomarker for assessing the risk of postoperative metastasis in LN- early-stage BC patients.
- To investigate the potential of gene expression profiling to predict outcomes in this patient group.
Main Methods:
- Gene expression profiling of 640 LN- early-stage BC samples from three public datasets.
- Univariable and multivariable Cox regression and distant metastasis-free survival (DMFS) analyses.
- Quantitative real-time polymerase chain reaction (qRT-PCR) validation in 25 clinical samples.
Main Results:
- Low expression of ADAMTS8 was consistently observed in LN- early-stage BC.
- Reduced ADAMTS8 expression correlated significantly with increased postoperative metastasis and shorter DMFS.
- Validation cohorts confirmed that lower ADAMTS8 expression is linked to poorer prognostic indicators and outcomes.
Conclusions:
- Low ADAMTS8 expression serves as a potential prognostic marker for postoperative metastasis in LN- early-stage BC.
- ADAMTS8 may play a role in BC metastasis, warranting further investigation.
- This finding could aid in stratifying patients for intensified treatment strategies.
