Related Experiment Video

Updated: Oct 7, 2025

Intratracheal Administration of Dry Powder Formulation in Mice
07:55

Intratracheal Administration of Dry Powder Formulation in Mice

Published on: July 25, 2020

11.1K

Design and Characterization of Atorvastatin Dry Powder Formulation as a potential Lung Cancer Treatment

Alaa S Tulbah1, Amr Gamal2

  • 1Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
|January 10, 2022
PubMed

Insights

Mannitol microcarriers enhance Atorvastatin (AVT) delivery for lung cancer, improving cellular uptake and anti-cancer effects. This novel pulmonary drug delivery system shows promise for sustained treatment and reduced mortality.

Area of Science:

  • Pharmacology
  • Biotechnology
  • Oncology

Background:

  • Lung cancer is a leading cause of cancer mortality.
  • Atorvastatin (AVT) has demonstrated beneficial effects in reducing mortality and improving survival in lung cancer patients.
  • Optimizing drug delivery systems is crucial for enhancing therapeutic efficacy.

Purpose of the Study:

  • To develop mannitol microcarriers for improved Atorvastatin (AVT) delivery in lung cancer treatment.
  • To enhance AVT's cytotoxic activity and cellular uptake via a pulmonary drug delivery system.
  • To evaluate the impact of improved inhalation deposition on dry powder formulation efficiency.

Main Methods:

  • Atorvastatin-loaded mannitol (AM) microparticles (AVT-AM) were prepared using spray drying.
  • Physicochemical properties, including particle size (3418 nm ± 26.86), and aerodynamic deposition were characterized.
  • In vitro cytotoxicity assays (proliferation, apoptosis, cell cycle) were performed on A549 lung adenocarcinoma cells.

Main Results:

  • The AVT-AM formulation exhibited good flow properties and aerosol deposition.
  • Compared to free AVT, the AVT-AM formulation showed significantly higher cellular uptake.
  • The formulation demonstrated enhanced anti-cancer properties by disrupting cell cycle progression through apoptosis or G2/M phase arrest.

Conclusions:

  • Mannitol microcarriers represent a promising strategy for improving Atorvastatin (AVT) delivery for lung cancer.
  • The developed AVT-AM formulation offers potential for effective and sustained pulmonary drug delivery.
  • This approach may lead to improved therapeutic outcomes and reduced mortality in lung cancer patients.
Keywords:
AerodynamicCytotoxicityDry Powder InhalerLung cancerMannitol

More Related Videos

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.0K
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

7.8K

Related Concept Videos

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
8
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
52.4K
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
6
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
3.3K