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Updated: Oct 7, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
[Addictive inhalants-A challenge for the lungs].
Claudia Bauer-Kemény1, Michael Kreuter1,2
1Pneumologie und Beatmungsmedizin, Thoraxklinik, Universitätsklinikum Heidelberg, Röntgenstraße 1, 69126 Heidelberg, Deutschland.
Inhaled psychotropic substances like e-cigarettes, cannabis, cocaine, and heroin pose risks. Research is lacking on novel products and cannabis, while cocaine and heroin cause documented lung damage with chronic use.
Area of Science:
- Pulmonology
- Toxicology
- Public Health
Context:
- Inhaled psychotropic substance use is prevalent, including tobacco, e-cigarettes, cannabis, cocaine, and heroin.
- While tobacco's lung effects are known, data on other inhaled substances is limited.
- Novel products like e-cigarettes and heated tobacco lack independent, standardized health risk data.
Purpose:
- To review the current scientific evidence on the health effects of various inhaled psychotropic substances on the lungs and respiratory tract.
- To identify knowledge gaps regarding novel inhaled products and cannabis use.
- To highlight documented lung damage from inhaled cocaine and heroin.
Summary:
- Evidence on the respiratory health impacts of e-cigarettes and heated tobacco products is insufficient.
- Long-term effects of cannabis inhalation on lung health remain unclear.
- Extensive and chronic inhalation of cocaine and heroin demonstrably causes significant lung damage.
Impact:
- Highlights the urgent need for standardized, independent research on novel inhaled substances.
- Informs public health strategies regarding the risks of widespread psychotropic substance inhalation.
- Underscores the severe pulmonary consequences of chronic cocaine and heroin use.
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