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Insulin-Like Growth Factor Binding Proteins in Kidney Disease
Shuqiang Wang1,2, Kun Chi1, Di Wu1
1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing, China.
Frontiers in Pharmacology
|January 10, 2022
Summary
Insulin-like growth factor binding proteins (IGFBPs) regulate gene expression, cell migration, and apoptosis, impacting kidney disease development. Specific IGFBPs are linked to diabetic nephropathy, FSGS, CKD, and AKI, highlighting their diagnostic and prognostic potential.
Area of Science:
- Nephrology
- Endocrinology
- Molecular Biology
Background:
- Insulin-like growth factor binding proteins (IGFBPs) were initially recognized for regulating IGFs.
- Recent research reveals IGFBP functions independent of IGFs, particularly in cellular processes.
- These IGFBP functions are implicated in the pathogenesis of various kidney diseases.
Purpose of the Study:
- To review the differential expression of IGFBPs in kidney disease.
- To elucidate the role of IGFBPs in the pathogenesis of kidney disease.
- To highlight the clinical relevance of IGFBPs in kidney disease diagnosis and prognosis.
Main Methods:
- Literature review of studies on IGFBP expression and function in kidney disease.
- Analysis of the association between specific IGFBPs and kidney disease types.
- Examination of IGFBP roles in cellular processes relevant to kidney pathophysiology.
Main Results:
- IGFBP-1, IGFBP-3, and IGFBP-4 are linked to diabetes and diabetic nephropathy.
- IGFBP-3, IGFBP-4, IGFBP-5, and IGFBP-6 are involved in apoptosis in diabetes, FSGS, and CKD.
- IGFBP-7 serves as a biomarker for acute kidney injury (AKI) diagnosis and prognosis.
Conclusions:
- IGFBPs play significant roles in kidney disease development and progression.
- Specific IGFBPs have distinct roles in various kidney pathologies.
- IGFBPs represent promising biomarkers for kidney disease management.
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