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Urinary Soluble CD163 Levels Predict IgA Nephropathy Remission Status.
Shaomin Gong1,2,3,4,5, Shi Jin1,2,3,4,5, Yang Li1,2,3,4,5
1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Frontiers in Immunology
|January 10, 2022
Summary
Urinary soluble CD163 (u-sCD163) indicates disease severity in IgA nephropathy (IgAN). Higher u-sCD163 levels predict a greater risk of remission failure in IgAN patients.
Area of Science:
- Nephrology
- Immunology
- Biomarker Discovery
Background:
- IgA nephropathy (IgAN) requires noninvasive biomarkers to predict disease activity and remission.
- Soluble CD163 (sCD163), released by macrophages, is a potential indicator in inflammatory conditions.
Purpose of the Study:
- To investigate the association between urinary sCD163 (u-sCD163) and disease characteristics in IgAN patients.
- To evaluate u-sCD163 as a predictive biomarker for IgAN remission failure.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure u-sCD163 in 349 biopsy-diagnosed IgAN patients.
- Correlation analysis was performed between u-sCD163 levels, histopathology, and clinical parameters.
- Risk prediction models were developed to assess the impact of u-sCD163 on remission failure.
Main Results:
- Elevated u-sCD163 levels correlated with more severe histological lesions, increased proteinuria, and reduced renal function.
- u-sCD163 levels showed a positive correlation with tubulointerstitial CD163+ macrophage infiltration.
- High u-sCD163 (>3.57 ng/mg Cr) was linked to a 2.66-fold increased risk of IgAN remission failure.
Conclusions:
- Urinary sCD163 serves as a valuable noninvasive biomarker for assessing IgAN disease severity.
- u-sCD163 improves the prediction of remission status in IgA nephropathy when combined with clinical data and MEST-C scores.
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