Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.8K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.8K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of multiphasic CT-based delta-radiomics model for predicting postoperative recurrence risk in bladder cancer.

BMC medical imaging·2026
Same author

The atlas of abdominal organ remodeling in hepatocellular carcinoma patients: An artificial intelligence-based multicenter imaging study.

Med (New York, N.Y.)·2026
Same author

Precision Surgery and Minimally Invasive Techniques for the Treatment of Complex Biliary Stones Closely Associated with the Middle Hepatic Vein.

Journal of visualized experiments : JoVE·2026
Same author

Preoperative lung immune prognostic index (LIPI) predicts postoperative outcomes in clear cell renal cell carcinoma: a multicenter study.

Scientific reports·2026
Same author

Hepatic immune prognostic index as a prognostic biomarker in hepatocellular carcinoma patients treated with transarterial chemoembolization.

Therapeutic advances in medical oncology·2026
Same author

Radiogenomic landscape of the hallmarks of cancer.

Biomarker research·2026

Related Experiment Video

Updated: Oct 7, 2025

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

8.9K

Rotavirus Interactions With Host Intestinal Epithelial Cells.

Joshua Oluoch Amimo1,2, Sergei Alekseevich Raev1, Juliet Chepngeno1

  • 1Center for Food Animal Health, Department of Animal Sciences, College of Food Agricultural and Environmental Sciences, The Ohio State University, Wooster, OH, United States.

Frontiers in Immunology
|January 10, 2022
PubMed
Summary

Rotavirus (RV) causes severe diarrhea in children by infecting intestinal cells. Understanding how RV interacts with intestinal epithelial cells (IECs) is key to developing new treatments and vaccines.

Keywords:
immune evasionimmune receptorsimmunityintestinal epithelial cellsrotaviruses pathogenesis

More Related Videos

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions
08:01

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions

Published on: January 19, 2024

1.5K
Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
07:59

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions

Published on: September 10, 2021

3.3K

Related Experiment Videos

Last Updated: Oct 7, 2025

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

8.9K
Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions
08:01

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions

Published on: January 19, 2024

1.5K
Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
07:59

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions

Published on: September 10, 2021

3.3K

Area of Science:

  • Virology
  • Immunology
  • Gastroenterology

Background:

  • Rotavirus (RV) is a major cause of severe diarrheal disease in young children globally.
  • RV infects mature enterocytes in the intestinal epithelium, leading to villus atrophy and cell death.
  • Intestinal epithelial cells (IECs) possess innate immune defenses against RV, but the virus has evolved mechanisms to evade them.

Purpose of the Study:

  • To comprehensively review the mechanisms of RV-IEC interactions.
  • To highlight the role of gut microbiota in RV infection.
  • To inform the development of novel antiviral therapies and vaccines.

Main Methods:

  • This is a review article, synthesizing existing research on RV-IEC interactions.
  • It examines the molecular mechanisms of RV cell entry and host immune evasion.
  • The role of host factors like sialic acid and microbiota is discussed.

Main Results:

  • RV utilizes specific host cell molecules (sialic acid, integrins) for attachment and entry.
  • RV subverts host cell machinery for replication and transmission.
  • Gut microbiota plays a role in RV infection dynamics.

Conclusions:

  • Understanding RV-IEC interactions is crucial for controlling RV infections.
  • Targeting specific immune antagonists within IECs could lead to effective antiviral strategies.
  • Further research into these mechanisms will aid in developing better vaccines and therapies.