Effect of Massive Transfusion Protocol on Coagulation Function in Elderly Patients with Multiple Injuries.

Area of Science:

• Trauma Care
• Coagulation Medicine
• Geriatric Medicine

Background:

• Elderly patients with multiple injuries face complex challenges in managing coagulation and preventing organ dysfunction.
• The effectiveness of massive transfusion protocols (MTP) in this specific demographic requires thorough investigation.

Purpose of the Study:

• To evaluate the impact of MTP on coagulation function and clinical outcomes in elderly patients with multiple injuries.
• To compare MTP with routine transfusion protocols in terms of hematological parameters, organ function, and patient prognosis.

Main Methods:

• A retrospective cohort study involving 94 elderly patients with multiple injuries.
• Comparison of patients receiving MTP (n=50) versus routine transfusion (n=44).
• Analysis of coagulation parameters, platelet counts, organ dysfunction scores, transfusion volumes, length of stay, complications, and mortality at 24 hours post-transfusion.

Main Results:

• MTP significantly improved hematocrit, platelets, and hemoglobin levels compared to routine transfusion.
• MTP led to better coagulation function (lower aPTT, PT, TT, fibrinogen) and reduced organ dysfunction scores (Marshall, SOFA).
• MTP was associated with decreased ICU and total length of stay and fewer complications, without increasing mortality.

Conclusions:

• MTP is beneficial for elderly patients with multiple injuries, enhancing coagulation and platelet parameters.
• MTP effectively alleviates organ dysfunction and reduces the incidence of complications in this patient group.
• Implementing MTP can improve the overall prognosis for elderly trauma patients.