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Updated: Oct 7, 2025
Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
PTPRO is a therapeutic target and correlated with immune infiltrates in pancreatic cancer
Xuben Hou1, Jintong Du2, Hao Fang1
1Department of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), Cheeloo College of Medicine, School of Pharmaeutical Science, Shandong University, Jinan, Shandong, 250012, China.
Abstract:
As a member of protein tyrosine phosphatases (PTPs), the protein tyrosine phosphatase receptor type O (PTPRO) has attracted increasing attention for its important roles in cell signaling. Currently, the roles of PTPRO in human cancers remain elusive. Herein, we performed bioinformatic analyses and revealed the potential oncogenic role of PTPRO in specific cancer types. Further in vitro experiments indicated that inhibition of PTPRO suppresses the proliferative abilities of tumor cells in pancreatic cancer, blood cancer, and breast cancer. Moreover, small molecular PTPRO inhibitor could induce cell apoptosis and affect the cell cycle in pancreatic cancer. In addition, PTPRO expression promoted the infiltration of CD8+ T, macrophages, dendritic cells, and neutrophils, in pancreatic cancers. Our findings suggested PTPRO may serve as a potential drug target for pancreatic cancer.
Insights
Protein tyrosine phosphatase receptor type O (PTPRO) shows oncogenic roles in cancers. Inhibiting PTPRO suppresses tumor cell proliferation and induces apoptosis, suggesting PTPRO as a potential pancreatic cancer drug target.
Area of Science:
- Biochemistry
- Oncology
- Immunology
Background:
- Protein tyrosine phosphatases (PTPs) are crucial in cell signaling.
- The specific roles of PTPRO in human cancers are not well understood.
- PTPRO is a member of the PTP superfamily.
Purpose of the Study:
- To investigate the role of PTPRO in human cancers.
- To explore PTPRO as a potential therapeutic target, particularly in pancreatic cancer.
Main Methods:
- Bioinformatic analyses were conducted.
- In vitro experiments were performed on tumor cell lines.
- Small molecule inhibitors targeting PTPRO were utilized.
Main Results:
- PTPRO was found to have a potential oncogenic role in specific cancer types.
- PTPRO inhibition suppressed tumor cell proliferation in pancreatic, blood, and breast cancers.
- In pancreatic cancer, PTPRO inhibition induced apoptosis and affected the cell cycle.
- PTPRO expression enhanced the infiltration of CD8+ T cells, macrophages, dendritic cells, and neutrophils in pancreatic cancers.
Conclusions:
- PTPRO plays a significant role in the progression of certain cancers.
- Targeting PTPRO may represent a viable therapeutic strategy for pancreatic cancer.
- Further research into PTPRO's function in cancer is warranted.
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