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Relationship between Expression of Plasma lncRNA-HEIH and Prognosis in Patients with Coronary Artery Disease

Zhenying Zhang1, Sushuang Nan2, Xiujuan Duan2

  • 1Cardiac Rehabilitation Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.

Disease Markers
|January 10, 2022
PubMed

Insights

Long noncoding RNA-HEIH (lncRNA-HEIH) is highly expressed in coronary artery disease (CAD) patients, correlating with disease severity and adverse cardiac events. This finding suggests lncRNA-HEIH impacts CAD patient prognosis.

Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Biomarker Discovery

Background:

  • Coronary artery disease (CAD) poses a significant global health burden.
  • Identifying novel biomarkers for CAD prognosis is crucial for patient management.

Purpose of the Study:

  • To investigate the expression levels of long noncoding RNA-HEIH (lncRNA-HEIH) in patients with CAD.
  • To determine the correlation between lncRNA-HEIH expression and CAD severity.
  • To assess the impact of lncRNA-HEIH on the prognosis of CAD patients.

Main Methods:

  • Plasma samples were collected from 250 patients (150 CAD, 50 control) undergoing coronary angiography.
  • lncRNA-HEIH expression was quantified using real-time quantitative polymerase chain reaction (qPCR).
  • CAD severity was assessed using the SYNTAX scoring system, and patients were followed for 3 years for major adverse cardiac events.

Main Results:

  • lncRNA-HEIH expression was significantly higher in CAD patients compared to controls.
  • Elevated lncRNA-HEIH levels correlated with increased CAD severity.
  • High lncRNA-HEIH expression was associated with higher rates of dyslipidemia, family history of CAD, and major adverse cardiac events.

Conclusions:

  • lncRNA-HEIH is upregulated in the plasma of CAD patients.
  • lncRNA-HEIH expression serves as a potential indicator for CAD severity and prognosis.
  • lncRNA-HEIH may play a role in the progression and outcomes of coronary artery disease.
Abstract

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