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Aging and Vascular Compliance in Hypertensive Patients Mirrored in Routine Investigations

Răzvan Balan1,2, Corina Ferdoschi1, Elena Bălăşescu1,3

  • 1"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Current Health Sciences Journal
|January 10, 2022
PubMed

Insights

Vascular compliance in hypertension can be estimated using HDL in older adults and RDW in younger individuals. These markers influence pulse pressure, aiding in hypertension management.

Area of Science:

  • Cardiology
  • Gerontology
  • Clinical Biochemistry

Background:

  • Arterial hypertension prevalence is rising globally, posing significant morbidity and mortality risks.
  • Effective diagnosis and management of hypertension are crucial due to its severe health consequences.

Purpose of the Study:

  • To analyze vascular compliance and pressure characteristics in hypertensive patients across different age groups.
  • To investigate clinical-paraclinical correlations, including the impact of age, using routine lab tests and 24-hour ambulatory blood pressure monitoring (ABPM).

Main Methods:

  • A study involving 99 adults diagnosed with hypertension, divided into two age groups: <60 years (control, n=47) and >60 years (cases, n=52).
  • Utilized standard laboratory analyses and ABPM/24 hr for blood pressure measurements.

Main Results:

  • In younger adults, Red Cell Distribution Width (RDW) correlated with systolic and diastolic hypertension indices and platelet count with morning surge; dipping profile negatively correlated with RDW.
  • In older adults, Erythrocyte Sedimentation Rate (ESR) influenced systolic blood pressure parameters, which negatively correlated with High-Density Lipoprotein (HDL).
  • Blood glucose correlated with diurnal systolic and diastolic hypertension indices. Mean Pulse Pressure correlated negatively with HDL in the elderly and positively with RDW in the young.

Conclusions:

  • HDL can estimate vascular compliance in the elderly, while RDW is useful in younger individuals.
  • Both HDL and RDW significantly influence pulse pressure, offering insights for hypertension management strategies.

Keywords:
Ambulatory blood pressure monitoring/24 hoursagehypertensionvascular compliance

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