Related Experiment Video
Updated: Oct 7, 2025

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis
Published on: June 10, 2022
A Cross-Sectional Study to Assess Thyroid Function in Infants and Children in a City from South-Western Romania
Corina Maria Vasile1,2, Alice Elena Ghenea3, Anca Loredana Udriştoiu4
1PhD School, University of Medicine and Pharmacy of Craiova, Romania.
Insights
Pediatric thyroid disorders, including autoimmune thyroiditis and hypothyroidism, are common. Early detection and treatment are crucial for preventing developmental issues in children with thyroid dysfunction.
Area of Science:
- Pediatric Endocrinology
- Thyroidology
- Child Health
Background:
- Thyroid hormones regulate critical bodily functions including growth, metabolism, and nervous system development.
- Thyroid disorders are the most common endocrinopathies in childhood, presenting differently than in adults.
- Early diagnosis and management of thyroid dysfunction in neonates are vital to prevent irreversible neurological damage and developmental delays.
Purpose of the Study:
- To investigate the function, structure, and prevalence of thyroid problems in children.
- To analyze the specific etiological factors and clinical presentations of thyroid disorders in pediatric populations.
Main Methods:
- A study was conducted on 30 children under 16 years old presenting with thyroid-related symptoms.
- Data collected included demographic and family history, thyroid ultrasounds, and blood tests for triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH).
Main Results:
- Females represented a slight majority of the study group (2.33:1 ratio).
- The prevalence of diagnosed conditions included autoimmune thyroiditis (46.7%), hypothyroidism (26.7%), subclinical hypothyroidism (13.3%), congenital hypothyroidism (6.67%), and hyperthyroidism (3.33%), with one case of Graves' disease.
Conclusions:
- Thyroid dysfunction in children requires specialized understanding due to unique etiological and clinical features.
- Autoimmune thyroiditis and hypothyroidism are significant concerns in the pediatric population studied.
- Further research into pediatric thyroid disorders is warranted to optimize diagnostic and therapeutic strategies.
Abstract:
Thyroid hormones are critical regulators of growth, myelination of the nervous system, metabolism, and organ function. The most prevalent endocrinopathies in childhood are related to thyroid disorders. Thyroid problems in children and adolescents have a significantly different etiology and clinical presentation than in adults. Thus, pediatric medical care involves an understanding of the unique features of thyroid function and dysfunction during childhood and adolescence. The etiology and clinical manifestations of thyroid disorders in children and adolescents are vastly different from those in adults. The particular aspects of thyroid function and malfunction in childhood and adolescence are hence part of pediatric medical therapy. To prevent persistent nervous system damage and developmental problems, it is vital to recognize and treat thyroid dysfunction in neonates as early as possible. The purpose of the research was to understand more how children's thyroid problems function, structure, and prevalence. The research examined 30 children under the age of 16 years who had symptoms that were linked to thyroid problems. In addition to demographic and family information, thyroid ultrasounds and blood samples for the detection of T3, T4, and TSH were obtained. Females surpassed males by a small majority (2.33:1 ratio).Out of the total children included in the study, 14(46.7%) cases for autoimmune thyroiditis, 2(6.67%) cases for congenital hypothyroidism, 1(3.33%) case for hyperthyroidism, 1(3.33%) case for hyperthyroidism-Graves disease, 8(26.7%) cases for hypothyroidism and 4(13.3%) cases for subclinical hypothyroidism.
Related Concept Videos
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Assessing Body Temperature - Oral
Step 1:
Start by practicing proper hand hygiene to prevent the spread of microorganisms.
Step 2:
Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
Step 3:
Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
Step 4:
Instruct the patient to open their mouth and place...

