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Non-Coding RNA m6A Modification in Cancer: Mechanisms and Therapeutic Targets

Da-Hong Chen1, Ji-Gang Zhang2, Chuan-Xing Wu3

  • 1Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Cell and Developmental Biology
|January 10, 2022
PubMed

Insights

N6-methyl-adenosine (m6A) RNA modification in non-coding RNAs is key to cancer progression. Understanding these m6A modifications offers new avenues for targeted cancer therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Epigenetics

Background:

  • N6-methyl-adenosine (m6A) is a prevalent internal RNA modification in eukaryotes.
  • Non-coding RNA m6A modifications are increasingly recognized for their roles in cancer.

Purpose of the Study:

  • To review the intricate relationship between non-coding RNA m6A modification and cancer progression.
  • To highlight the molecular mechanisms and clinical applications of m6A in various cancers.

Main Methods:

  • Literature review focusing on m6A modification in non-coding RNAs and cancer.
  • Analysis of key cancer progression mechanisms influenced by m6A.

Main Results:

  • Non-coding RNA m6A modifications are significantly associated with tumorigenesis, metastasis, and tumor characteristics.
  • m6A modifications act as crucial regulators in cancer proliferation, apoptosis, invasion, metastasis, and angiogenesis.

Conclusions:

  • Non-coding RNA m6A modification is a critical factor in cancer progression with broad research prospects.
  • Targeted m6A-based therapies hold significant potential for cancer treatment.
Keywords:
cancer therapyepigeneticsm6A RNA modificationnon-coding RNAtumorigenesis mechanism

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