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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

390
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
250
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

328
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
328

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Related Experiment Video

Updated: Oct 7, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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Innovative Approaches to Assess Intermediate Cardiovascular Risk Subjects: A Review From Clinical to Metabolomics

Aline M A Martins1,2,3, Mariana U B Paiva2, Diego V N Paiva2

  • 1Centre of Metabolomics and Bioanalysis (CEMBIO), San Pablo CEU University, Madrid, Spain.

Frontiers in Cardiovascular Medicine
|January 10, 2022
PubMed
Summary

Metabolomics screening offers a powerful new approach to improve coronary artery disease (CAD) risk stratification in intermediate-risk individuals. This method enhances non-invasive diagnostics, potentially preventing inadequate preventive therapies for cardiovascular events.

Keywords:
atherosclerosiscardiovascular preventioncoronary artery disease (CAD)metabolomicsrisk stratification

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Area of Science:

  • Cardiovascular Medicine
  • Metabolomics
  • Biomarker Discovery

Background:

  • Current coronary artery disease (CAD) risk stratification has limited predictive value in asymptomatic, intermediate-risk individuals.
  • Atherosclerotic plaques can be silent, leading to sudden cardiac death or acute coronary syndrome as initial manifestations.
  • Inaccurate risk assessment can result in suboptimal preventive therapies.

Purpose of the Study:

  • To review the role of metabolomics integrated with traditional assessments for improved non-invasive CAD subclinical diagnostics.
  • To critically evaluate the findings from mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) in metabolomics studies.
  • To discuss the challenges and potential for clinical implementation of metabolomics in cardiovascular risk stratification.

Main Methods:

  • Review of current literature on metabolomics applications in cardiovascular disease.
  • Analysis of findings from studies utilizing mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR).
  • Discussion of the pathophysiology of atherosclerosis and limitations of traditional risk assessment methods.

Main Results:

  • Metabolomics screening, combined with traditional risk factors, shows promise for enhancing non-invasive CAD diagnostics.
  • Discriminant metabolites identified through metabolomics can aid in stratifying intermediate-risk patients.
  • Analytical platforms like MS and NMR are key to current metabolomics research in this field.

Conclusions:

  • Metabolomics represents a powerful approach to improve cardiovascular risk stratification, particularly for intermediate-risk individuals.
  • Identified metabolic biomarkers hold potential for clinical translation, aiding in more precise patient management.
  • Addressing challenges in data implementation is crucial for integrating metabolomics into clinical practice.