Related Experiment Video
Updated: Oct 7, 2025
08:34
Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
Published on: April 21, 2016
16.9K
Hydrogel based tissue engineering and its future applications in personalized disease modeling and regenerative
Shikha Chaudhary1, Eliza Chakraborty2
1SRM Institute of Science & Technology, Chennai, Tamil Nadu 603203 India.
Beni-Suef University Journal of Basic and Applied Sciences
|January 10, 2022
Summary
Three-dimensional (3D) organoid culture offers advanced physiological insights, overcoming animal model limitations for drug discovery and personalized medicine. This innovative approach enhances organ transplantation and disease modeling capabilities.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Cell Biology
Background:
- Conventional 2D cell culture has evolved to 3D techniques, offering better physiological insights into the human body.
- Increasing demand for organ transplantation, anti-cancer drug screening, and limitations of animal models drive interest in 3D organ culture.
Purpose of the Study:
- To review novel organoid culture approaches.
- To discuss the advantages and limitations of organoid technology.
- To explore applications in life sciences, including cancer research, cell therapy, tissue engineering, personalized medicine, and drug discovery.
Main Methods:
- Utilizing natural, synthetic, and hybrid hydrogels as scaffolds for 'close-to-in vivo' 3D structures.
- Employing stem cell-derived organoids that mimic in-vivo organ/tissue conditions.
- Leveraging 3D bioprinting to address vascularization challenges in organoid culture.
Main Results:
- Organoids provide a more accurate model for clinical applications compared to animal models.
- 3D bioprinting facilitates the creation of vascularized organoids.
- Organoid technology shows significant promise in personalized disease modeling and rapid drug development.
Conclusions:
- Organoid culture represents a significant advancement in in vitro modeling.
- This technology has broad applications in personalized medicine and drug discovery.
- Further research into organoid advantages and limitations will refine their use in various life science fields.
