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Related Experiment Video

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Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor

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Bilateral Paraneoplastic Vitritis: A Case Report.

Ezgi Karatas Yigitaslan¹, Eyup Sabri Ucan², Nurullah Akkoc³

¹Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.

Beyoglu Eye Journal

|January 10, 2022

Summary

Bilateral vitritis, an eye condition, can signal small-cell lung cancer (SCLC). Early detection through ocular symptoms may lead to timely cancer diagnosis and treatment.

Keywords:

Paraneoplastic syndrome small-cell lung cancer uveitis vitritis

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Area of Science:

Ophthalmology
Oncology
Medical Case Reports

Background:

Ocular inflammation can be a presenting sign of systemic disease.
Paraneoplastic syndromes involve immune responses to cancer affecting non-cancerous tissues.
Small-cell lung cancer (SCLC) is an aggressive form of lung cancer.

Observation:

A 70-year-old male presented with gradual, bilateral visual deterioration.
Ophthalmological examination revealed symmetrical vitritis in both eyes without other fundus abnormalities.
The patient reported a history of smoking, weight loss, and was diagnosed with SCLC.

Findings:

The patient was diagnosed with bilateral paraneoplastic vitritis.
Systemic evaluation confirmed small-cell lung cancer (SCLC).
Ocular inflammation resolved with oral steroid treatment and cancer therapy.

Implications:

Ocular manifestations, such as vitritis, can serve as an early indicator of underlying malignancy.
Ophthalmologists should consider systemic evaluation for malignancy in patients with unexplained bilateral vitritis.
Prompt diagnosis and treatment of SCLC, potentially aided by ophthalmological findings, can improve patient outcomes.