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Ventricular repolarization heterogeneity in patients with COVID-19: Original data, systematic review, and

Elham Mahmoudi1,2, Reza Mollazadeh2, Pejman Mansouri3

  • 1Gerash Amir-al-Momenin Medical and Educational Center, Gerash University of Medical Sciences, Gerash, Iran.

Clinical Cardiology
|January 10, 2022
PubMed

Insights

COVID-19 significantly impacts heart repolarization, increasing ECG markers like TpTe interval and TpTe/QT ratio. These findings highlight potential cardiac risks associated with the virus.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Infectious Diseases

Background:

  • COVID-19 is linked to increased acute cardiac events.
  • The impact of COVID-19 on cardiac repolarization heterogeneity remains unclear.
  • This study investigates ECG markers of repolarization in COVID-19 patients.

Purpose of the Study:

  • To evaluate ECG markers of repolarization heterogeneity in hospitalized COVID-19 patients.
  • To compare these markers between COVID-19 patients and non-COVID-19 controls.
  • To conduct a systematic review and meta-analysis of relevant published studies.

Main Methods:

  • Calculated QT dispersion (QTd), TpTe interval, TpTe/QT ratio, QRS width, and iCEB in 101 COVID-19 patients and 101 matched controls.
  • Performed a systematic review across four databases.
  • Conducted a meta-analysis using Stata software.

Main Results:

  • COVID-19 patients showed significantly increased TpTe interval, TpTe/QT ratio, QRS width, and iCEB compared to controls.
  • Meta-analysis of 679 COVID-19 cases and 526 controls confirmed increased TpTe interval, TpTe/QT, and TpTe/QTc ratios.
  • QTd did not show a significant correlation with COVID-19.

Conclusions:

  • COVID-19 adversely affects ECG markers of transmural repolarization heterogeneity.
  • Further research is needed to determine the clinical utility of these ECG markers for predicting outcomes.
Abstract

Keywords:
COVID-19QT dispersionT-peak to T-endelectrocardiographyrepolarization disparityrepolarization heterogeneitysudden cardiac death

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