Quaternized Polydopamine Coatings for Anchoring Molecularly Dispersed Broad-Spectrum Antimicrobial Silver Salts

Because of the broad-spectrum antimicrobial efficacy, silver-based coatings have emerged as the popular choice to apply over frequently touched surfaces for mitigating the spread of nosocomial infections. Despite the advancements through various coating strategies, clustering of the active component remains a bottleneck in achieving the molecular-scale dispersion of silver. To circumvent this, the current study takes advantage of the recent findings of quaternary ammonium moieties forming molecular complexes with silver salts that differ from the simple adduct between the individual components. Here we demonstrate the quaternization of oxidatively cross-linked polydopamine coatings over magnetite nanoparticles to anchor ionic silver at a molecular-scale dispersion. The silver-derivatized materials exhibit remarkable broad-spectrum antimicrobial properties against representative microbes like E. coli, S. aureus, and A. niger. Also, the study reveals the materials' antibiofilm efficacy (∼80-90%) against both bacteria. Further recyclability studies have proven the sustained bactericidal properties up to five cycles. The surface derivatization strategy has then been extended to cover glass slips that have also shown the retention of the bactericidal properties even after wiping 20 times with artificial sweat. The biocompatibility of the materials has been ascertained with treated water against the mouse fibroblast and human embryonic kidney cell lines. The current study offers insights in developing coatings with molecular-scale dispersion of ionic silver to achieve broad-spectrum antimicrobial properties in an atom-economical and sustainable manner.