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Updated: Jul 25, 2026

Processing of Human Reduction Mammoplasty and Mastectomy Tissues for Cell Culture
Published on: January 3, 2013
American Society of Plastic Surgeons Evidence-Based Clinical Practice Guideline Revision: Reduction Mammaplasty
Galen Perdikis1, Claire Dillingham1, Stefanos Boukovalas1
1From the Department of Plastic Surgery, Vanderbilt University Medical Center; Cone Health Medical Group; University of Texas M. D. Anderson Cancer Center; Division of Plastic Surgery, University of North Carolina at Chapel Hill; American Academy of Orthopaedic Surgeons; McMaster University; American Society of Plastic Surgeons; Nursing and Allied Health Research Office, Baptist Health Lexington; Division of Plastic Surgery, Department of Surgery, University of Pennsylvania Health System, Penn Presbyterian Hospital; University of California, Davis School of Medicine; Department of Plastic and Oral Surgery, Boston Children's Hospital; Harvard Medical School; Avera Medical Group; Columbia University Medical Center/New York-Presbyterian Hospital; University of Maryland; Ohio State University College of Medicine; and Division of Plastic and Reconstructive Surgery, Northwell Health.
Summary:
A multidisciplinary work group involving stakeholders from various backgrounds and societies convened to revise the guideline for reduction mammaplasty. The goal was to develop evidence-based patient care recommendations using the new American Society of Plastic Surgeons guideline methodology. The work group prioritized reviewing the evidence around the need for surgery as first-line treatment, regardless of resection weight or volume. Other factors evaluated included the need for drains, the need for postoperative oral antibiotics, risk factors that increase complications, a comparison in outcomes between the two most popular techniques (inferior and superomedial), the impact of local anesthetic on narcotic use and other nonnarcotic pain management strategies, the use of epinephrine, and the need for specimen pathology. A systematic literature review was performed, and an established appraisal process was used to rate the quality of relevant scientific research (Grading of Recommendations Assessment, Development and Evaluation methodology). Evidence-based recommendations were made and strength was determined based on the level of evidence and the assessment of benefits and harms.
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