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Updated: Oct 7, 2025

Author Spotlight: Advancing Pathogen Diagnostics with Standardized LAMP
Published on: September 8, 2023
Uncovering mechanisms of RT-LAMP colorimetric SARS-CoV-2 detection to improve assay reliability
Gianmarco D Suarez1,2, Domenick A Suarez2, Yuki Yu Kiu Tang2
1Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
Abstract:
Improved diagnostics are needed to manage the ongoing COVID-19 pandemic. In this study, we enhanced the color changes and sensitivity of colorimetric SARS-CoV-2 RT-LAMP assays based on triarylmethane dyes. We determined a mechanism for the color changes and obtained sensitivities of 10 RNA copies per microliter.
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