The bone marrow niche components are adversely affected in sepsis

Area of Science:

• Immunology
• Hematology
• Pathology

Background:

• Sepsis-induced multiple organ dysfunction is a leading cause of mortality.
• The impact of sepsis on the bone marrow (BM) niche and its cellular components remains understudied.

Purpose of the Study:

• To investigate the early pathological changes in the mouse bone marrow (BM) niche during sepsis.
• To analyze alterations in vascular structures, mesenchymal stem cells, and regulatory T cells within the BM niche.

Main Methods:

• Established mouse models of sepsis using lipopolysaccharide (LPS) injection and cecal ligation and puncture (CLP).
• Observed and analyzed major BM niche components, including vascular structures, mesenchymal stem cells, and regulatory T cells (Tregs).

Main Results:

• Bone marrow (BM) pathological changes were observed earlier and were more pronounced than in other organs.
• Significant alterations in BM niche cell components were detected, including transient increases in vascular endothelial cells with remodeling.
• A sustained decrease in regulatory T cells (Tregs) was observed over time.

Conclusions:

• Sepsis induces early and prominent pathological changes in the bone marrow (BM).
• The BM niche undergoes significant adaptive cellular changes in response to sepsis.
• Alterations in vascular endothelial cells and regulatory T cells are key features of the BM response to sepsis.