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Comparable clinical course between coagulase-negative staphylococcal and Staphylococcus aureus endocarditis.
Marie Bourget1,2, Marie Pasquie3, Hélène Charbonneau4
1Infectiology Unit, Clinique Pasteur, Toulouse, France. mariejudithjeanne@gmail.com.
Infection
|January 10, 2022
Summary
Staphylococcus aureus (SA) endocarditis and coagulase-negative staphylococci (CNS) endocarditis show similar complication rates, surgical needs, and mortality. This suggests pathogen type may not significantly impact outcomes in infectious endocarditis (IE).
Area of Science:
- Cardiology
- Infectious Diseases
- Microbiology
Background:
- Staphylococcus aureus (SA) is a common cause of infectious endocarditis (IE), often linked to worse outcomes than other pathogens.
- Coagulase-negative staphylococci (CNS) also cause IE, but comparative outcomes are less understood.
Purpose of the Study:
- To compare morbidity and mortality between IE caused by Staphylococcus aureus (E-SA) and IE caused by coagulase-negative staphylococci (E-CNS).
Main Methods:
- Retrospective cohort analysis of 428 IE patients from 2010-2017.
- Compared lengths of stay, complications (septic embolism), need for cardiac surgery, and in-hospital/1-year mortality between E-SA and E-CNS groups.
Main Results:
- Of 102 staphylococcal IE cases, 50 were E-SA and 52 were E-CNS.
- Septic embolism, cardiac surgery rates, and in-hospital/1-year mortality were comparable between E-SA and E-CNS groups.
- A significant proportion of staphylococcal IE occurred post-cardiac procedure.
Conclusions:
- Morbidity and mortality appear similar for E-SA and E-CNS.
- The specific staphylococcal pathogen (SA vs. CNS) may not be a primary determinant of IE outcomes.
- Further research may explore other factors influencing IE prognosis.
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