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Updated: Oct 7, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
Harnessing Multifaceted Next-Generation Technologies for Improved Skin Wound Healing
Bibrita Bhar1, Dimple Chouhan1, Nakhul Pai1
1Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Advanced bioengineering, nanotechnology, and 3D bioprinting offer new solutions for chronic wound healing. These cutting-edge technologies promise improved skin regeneration and cost-effective treatments.
Area of Science:
- Bioengineering
- Biomaterials Science
- Regenerative Medicine
Background:
- Chronic wounds impair skin regeneration due to dysregulated healing processes.
- Conventional dressings are often ineffective in addressing the complex pathophysiology of chronic wounds.
- Tissue engineering offers accelerated healing but faces scalability and cost challenges.
Purpose of the Study:
- To review recent advancements in wound healing strategies.
- To explore the integration of bioengineering, nanotechnology, and 3D bioprinting in wound care.
- To discuss the potential of wearable technology and advanced delivery devices for wound management.
Main Methods:
- Review of multidisciplinary approaches including bioengineering, nanotechnology, and 3D bioprinting.
- Focus on wearable technology for wound microenvironment monitoring.
- Analysis of advanced devices for controlled delivery of nanotherapeutics and external stimuli.
Main Results:
- Emerging technologies overcome limitations of conventional therapies for chronic wounds.
- Wearable technology enables comprehensive monitoring of wound healing.
- Advanced devices facilitate precise delivery of therapeutic agents and stimuli.
Conclusions:
- Technological advancements actively influence skin regeneration for improved wound treatment.
- These innovations hold potential for affordable and effective wound care solutions.
- The field shows promising clinical relevance and future prospects.
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