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Related Experiment Videos

Color vision defects in sickle cell anemia.

M S Roy1, G Rodgers, R Gunkel

  • 1National Eye Institute, Clinical Branch, Bethesda, MD.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|December 1, 1987
PubMed
Summary

Patients with sickle cell anemia often experience color vision defects, specifically blue-yellow impairments, even without visible posterior retinal changes. This study highlights potential vision issues beyond typical ophthalmoscopic findings in sickle cell patients.

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Area of Science:

  • Ophthalmology
  • Hematology
  • Genetics

Background:

  • Sickle cell anemia is a genetic blood disorder with potential ocular complications.
  • Peripheral retinopathy is a known complication, but posterior segment involvement is less understood.
  • Color vision is crucial for daily function and can be affected by various conditions.

Purpose of the Study:

  • To investigate color vision differences in sickle cell anemia patients compared to healthy controls.
  • To determine if color vision defects correlate with the severity of peripheral retinopathy or foveal avascular zone in sickle cell patients.

Main Methods:

  • Utilized the Farnsworth-Munsell 100-hue test to assess color vision.
  • Compared patients with sickle cell anemia (with specific visual acuity and retinopathy criteria) to matched normal controls.

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  • Analyzed associations between color vision scores and retinal findings.

    • Main Results:

    • Sickle cell anemia patients demonstrated significantly more blue-yellow and mixed color vision defects.
    • Patients with sickle cell anemia had higher Farnsworth-Munsell 100-hue test scores, indicating poorer color discrimination.
    • No significant correlation was found between color vision defects and the extent of peripheral retinopathy or foveal avascular zone size.

    Conclusions:

    • Color vision defects are prevalent in sickle cell anemia patients, even in the absence of posterior retinal abnormalities.
    • The Farnsworth-Munsell 100-hue test can detect subtle color vision impairments in this population.
    • These findings suggest a need for comprehensive ophthalmological evaluation beyond standard fundus examination for sickle cell patients.