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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Perylenequinone derivatives from the endolichenic fungus Phialocephala fortinii
Jintong Song1, Fei Xie1,2, Xiaoyi Luan1
1Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, P.R. China.
Abstract:
Five undescribed perylenequinone derivatives (PQDs) phialocephalarins H - L (1 - 5), together with two known PQDs phialocephalarins A - B (6, 7) and one known spirobisnaphthalene palmarumycin P3 (8) were isolated from the endolichenic fungus Phialocephala fortinii. Their structures were elucidated on the basis of NMR and HRESIMS data as well as electronic circular dichroism (ECD) calculations. Compounds 1, 2, 4, and 6 - 8 were evaluated for cytotoxic activities against NCI-H460, NCI-H446, PC3, and EC109 cell lines. The results showed that compounds 1, 2, 6, and 8 showed cytotoxic activities against EC109 cells with IC50 values ranging from 24.5 to 33.3 μM.
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