A new antiprotozoal compound from Calendula officinalis

A new phytoconstituent; (6Z,9Z)-heptadeca-6,9-diene-5,11-dione (1) was isolated from Calendula officinalis methanol extract. The structure of 1 was determined based on the analysis of NMR spectra and HRESIMS. It was tested for antimicrobial and antiprotozoal activities. Compound 1 showed leishmanicidal activity against L. donovani amastigote with an IC₅₀ of 16.4394 µM and IC₉₀ of 28.9015 µM and a weak antitrypanosomal activity with an IC₅₀ of 37.6136 µM. The cytotoxicity of 1 was evaluated using standard experimental procedures against THP1 cells and no cytotoxicity was observed indicating its selectivity and safety.Supplemental data for this article can be accessed here.