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Long non-coding RNAs in gastrointestinal cancers: Implications for protein phosphorylation

Tao Su1, Teng Wang1, Nasha Zhang2

  • 1School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Biochemical Pharmacology
|January 10, 2022
PubMed

Insights

Long non-coding RNAs (lncRNAs) precisely regulate protein phosphorylation in gastrointestinal (GI) cancers. Targeting lncRNAs offers potential for novel precision therapeutics by modulating cancerous signaling pathways.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Protein phosphorylation is a key post-translational modification crucial for cellular signaling.
  • Aberrant protein phosphorylation is implicated in the dysregulation of cancer-related signaling pathways.
  • Long non-coding RNAs (lncRNAs) have emerged as critical regulators in cancer biology.

Purpose of the Study:

  • To review the multidimensional roles of lncRNAs in modulating protein phosphorylation.
  • To explore how lncRNAs regulate cancerous signaling pathways in gastrointestinal (GI) cancers.
  • To discuss the prognostic impact of lncRNA-mediated phosphorylation in GI malignancies.

Main Methods:

  • Systematic review of recent advances in lncRNA research.
  • Analysis of lncRNA interactions with proteins and their impact on phosphorylation.
  • Examination of lncRNA roles in hepatocellular, colorectal, gastric, esophageal, and pancreatic cancers.

Main Results:

  • LncRNAs regulate protein phosphorylation through direct binding, interaction with partner proteins, or via encoded small peptides.
  • These regulatory mechanisms influence key protein phosphorylation events in cancer signaling.
  • LncRNAs play a significant role in the progression and prognosis of various GI cancers.

Conclusions:

  • LncRNAs are pivotal in controlling protein phosphorylation within cancer signaling networks.
  • Understanding lncRNA-mediated phosphorylation provides insights into GI cancer pathogenesis.
  • Targeting lncRNAs involved in key protein phosphorylation presents a promising avenue for precision cancer therapeutics.
Keywords:
Gastrointestinal cancerOncogeneProtein phosphorylationTumor suppressorlncRNAs

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