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Long non-coding RNAs in gastrointestinal cancers: Implications for protein phosphorylation
Tao Su1, Teng Wang1, Nasha Zhang2
1School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Biochemical Pharmacology
|January 10, 2022
Summary
Long non-coding RNAs (lncRNAs) precisely regulate protein phosphorylation in gastrointestinal (GI) cancers. Targeting lncRNAs offers potential for novel precision therapeutics by modulating cancerous signaling pathways.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Protein phosphorylation is a key post-translational modification crucial for cellular signaling.
- Aberrant protein phosphorylation is implicated in the dysregulation of cancer-related signaling pathways.
- Long non-coding RNAs (lncRNAs) have emerged as critical regulators in cancer biology.
Purpose of the Study:
- To review the multidimensional roles of lncRNAs in modulating protein phosphorylation.
- To explore how lncRNAs regulate cancerous signaling pathways in gastrointestinal (GI) cancers.
- To discuss the prognostic impact of lncRNA-mediated phosphorylation in GI malignancies.
Main Methods:
- Systematic review of recent advances in lncRNA research.
- Analysis of lncRNA interactions with proteins and their impact on phosphorylation.
- Examination of lncRNA roles in hepatocellular, colorectal, gastric, esophageal, and pancreatic cancers.
Main Results:
- LncRNAs regulate protein phosphorylation through direct binding, interaction with partner proteins, or via encoded small peptides.
- These regulatory mechanisms influence key protein phosphorylation events in cancer signaling.
- LncRNAs play a significant role in the progression and prognosis of various GI cancers.
Conclusions:
- LncRNAs are pivotal in controlling protein phosphorylation within cancer signaling networks.
- Understanding lncRNA-mediated phosphorylation provides insights into GI cancer pathogenesis.
- Targeting lncRNAs involved in key protein phosphorylation presents a promising avenue for precision cancer therapeutics.
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