Atopic Eczema: How Genetic Studies Can Contribute to the Understanding of this Complex Trait

Atopic eczema is an itchy inflammatory skin disease. This complex trait results from multiple genetic and environmental factors, but atopic eczema also shows great complexity in its heterogeneous presentation, clinical signs, and longitudinal trajectory, with or without comorbid conditions. The past 50 years have resulted in substantial improvements in the management of atopic eczema, but many patients still suffer a burden of disease affecting personal, social, and family life. Genetic research refocused interest on skin barrier function, but effective targeting of this central pathomechanism remains elusive. This perspective highlights the progress in understanding the molecular mechanisms and translational opportunities for the future.