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Allergy-induced systemic inflammation impairs tendon quality.

Christine Lehner1, Gabriel Spitzer1, Patrick Langthaler2

  • 1Institute of Tendon and Bone Regeneration, Spinal Cord Injury & Tissue Regeneration Center Salzburg, Paracelsus Medical University, Strubergasse 22, Salzburg 5020, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria.

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|January 10, 2022
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Systemic inflammation from allergies negatively impacts tendon health, leading to reduced mechanical properties and increased risk of tendinopathy. This study links allergic conditions to tendon degeneration, highlighting inflammation

Keywords:
AllergySystemic inflammationTendinopathyTendon

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Area of Science:

  • Orthopedics and Sports Medicine
  • Immunology
  • Biomaterials Science

Background:

  • Tendinopathies are challenging to treat due to poorly understood etiology.
  • Systemic inflammation, associated with conditions like rheumatoid arthritis, diabetes, obesity, and smoking, is a known predisposing factor.
  • The role of systemic inflammation in tendinopathy onset requires further investigation.

Purpose of the Study:

  • To investigate the impact of systemic inflammation, induced by an allergic episode, on tendon properties.
  • To determine if allergic conditions contribute to the development of tendinopathy.

Main Methods:

  • Induced allergic response in mice via timothy grass pollen exposure.
  • Analyzed biomechanical and histological properties of mouse flexor and Achilles tendons.
  • Examined human health survey data from over 10,000 individuals for allergy-tendinopathy association.

Main Results:

  • Allergic mice exhibited significantly reduced tendon elastic modulus and tensile stress.
  • Histological analysis revealed alterations in tendon matrix composition in allergic mice.
  • Human data indicated an increased propensity for tendinopathy in individuals with allergies.
  • Increased expression of macrophage markers and matrix metalloproteinase 2 (MMP2) observed in allergic Achilles tendons.

Conclusions:

  • Systemic inflammation associated with allergic conditions detrimentally affects tendon structure and function.
  • Allergies represent a significant risk factor for developing tendinopathy.
  • Findings underscore the link between systemic inflammatory conditions and tendon degeneration.